New 9,19-cycloartane triterpenoid from the root of Cimicifuga foetida

AIM:To study the 9,19-cycloartane triterpenes from the roots of Cimicifuga foetida.METHOD:Chromatographic separations by silica gel,C18 reversed phase silica gel,and high-performance liquid chromatography(HPLC) were used.All of the structures were elucidated on the basis of spectroscopic analysis and chemical methods.RESULTS:Five 9,19-cycloartane triterpenes,(3,12,15,24R)-12,2'-diacetoxy-24,25-epoxy-15-hydroxy-16,23-dione-3-O--L-arabinopyranoside(1),actein(2),23-epi-26-deoxyactein(3),asiaticoside B(4),and 12-hydroxycimigenol(5) were isolated from the roots of Cimicifuga foetida.CONCLUSION:Compound 1 is a new triterpene with two acetoxy groups at C-2'and C-12.