Chemical profiling of Jinqi Jiangtang tablets by HPLC-ESI-Q-TOF/MS

AIM:To profile the chemical constituents in Jinqi Jiangtang tablets.METHOD:Based on the chromatographic retention behavior,fragmentation patterns of chemical components,and published literatures,a high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC-ESI-Q-TOF/MS) method was established to characterize and identify components in Jinqi Jiangtang tablets.RESULTS:A total of 52 chemical compounds,including eight iridoid glycosides,seven phenolic acids,twelve alkaloids,six flavonoids,and nineteen saponins,were identified in Jinqi Jiangtang tablets.CONCLUSION:The established method could serve as a powerful tool for structural characterization and quality control of this Chinese herbal preparation.