Antifertility activity of Artemisia vulgaris leaves on female Wistar rats

AIM:To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.METHOD:The plant extract was tested for its effect on implant formation at two dose levels,300 and 600 mg·kg-1,respectively.The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.RESULTS:The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract,which shows a strong and significant decrease in implant formation(100%),and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats.These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.CONCLUSION:The methanolic plant extract of A.vulgaris has antifertility activity.