Mixed nanomicelles loaded with thymopeptides-sodium deoxycholate/phospholipid improve drug absorption

AIM:To improve the absorption of thymopeptides(TH) by preparing sodium deoxycholate/phospholipid-mixed nanomicelles(SDC/PL-MMs).METHODS:TH-SDC/PL-MMs were prepared by a film dispersion method,and then evaluated using photon correlation spectroscopy(PCS),zeta potential measurement,as well as their physical stability after storage for several days.Furthermore,in situ intestinal single-pass perfusion experiments and pharmacodynamics in immunodeficient mice were performed to make a comparison with TH powders and the control drug in absorption properties.RESULTS:A narrow size distribution of nanomicelles,with a mean particle size of(1498.32) nm and a zeta potential of(-31.052.52) mV,was obtained.The in situ intestine perfusion experiments demonstrated a significant advantage in absorption characteristics for TH compared to the other formulations,and oral administration of TH-SDC/PL-MMs potentiated an equivalent effect with i.h.TH in pharmacodynamic studies in immunodeficient mice.CONCLUSIONS:TH-SDC/PL-MMs prepared by a film dispersion method are able to improve the absorption of TH.SDC/PL-MMs might be a good approach for the more effective delivery of drugs like TH.