Triterpenoid saponins from Patrinia scabra

AIM:To study the chemical constituents and bioactivity of the roots of Patrinia scabra Bunge.METHODS:The chemical constituents were isolated using various chromatographic methods,and the structures were elucidated on the basis of spectral analysis and chemical methods.In addition,cytotoxic activities toward HepG2 cells were tested by the MTT method.RESULTS:A new triterpenoid saponin,3-O-(4'-isovaleryl)-O--D-xylose-12,30-dihydroxy-oleanane-28,13-lactone-22-O--D-glucoside(1),along with two known triterpenoid saponins,acanthopanax saponin CP3(2) and foetoside C(3),were isolated.CONCLUSION:The aglycone of compound 1 was a new skeleton derivative of oleanolic acid.Compound 2 showed strong cytotoxicity to HePG2 cells(IC50 1.49 molL-1).