Antiulcer activity of a polyherbal formulation(PHF) from Indian medicinal plants

AIM:The present study was aimed at evaluating the antiulcer activity of the polyherbal formulation(PHF) containing the leaf extracts of Moringa oleifera,Raphinus sativus,and Amaranthus tricolor in rats.METHODS:The antiulcer activity of the polyherbal formulation(PHF) was evaluated using different models of gastric ulcers:ethanol-induced,indomethacin-induced and ischemia reperfusion-induced gastric ulcers.Efficacy was assessed by determining the ulcer index.RESULTS:Administration of the polyherbal formulation(150 mgkg-1,p.o.) offered significant protection against indomethacin-induced,ethanol-induced,and ischemic reperfusion-induced ulcer models when compared to the control group.CONCLUSION:PHF,containing leaf extracts of Moringa oleifera,Raphinus sativus,and Amaranthus tricolor,was found to possess antiulcer properties in three experimental animal models of gastric ulcers,and these findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity.