A new guaiane-type sesquiterpene lactone from the Chinese liverwort Porella acutifolia subsp. tosana

AIM:To study the chemical constituents of the Chinese liverwort Porella acutifolia subsp.tosana.METHODS:The compounds were isolated and purified with column chromatography and their structures were determined on the basis of 1D-and 2D-NMR analysis.RESULTS:Three compounds were obtained and identified as guaian-3-en-2,14-6,12-diolide(1),(20R)-6-hydroxystigmasta-4,22-dien-3-one(2),and(20R)-3-hydroxystigmasta-5,22-dien-7-one(3).CONCLUSION:Compound 1 is a new guaiane-type sesquiterpene lactone.Compounds 2 and 3 are known steroids.