Two new cassane diterpenoids from the seeds of Caesalpinia sappan Linn.
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Graphical Abstract
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Abstract
AIM: To study the chemical components of the seeds of Caesalpinia sappan. METHODS: Compounds were isolated and purified by column chromatography. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activity of these compounds were evaluated using SF-268, MCF-7 and HepG2 cell lines by the MTT assay. RESULTS: Four cassane diterpenoids were obtained and their structures were identified as phanginin L (1), phanginin M (2), phanginin I (3), phanginin G (4). CONCLUSION: Phanginin L (1) and phanginin M (2) are new cassane diterpenoids. Compound 1 showed moderate cytotoxicity against HepG2 cell line with IC50 of 9.13 gmL-1.
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