Two new diterpenoid lactones isolated from <i>Andrographis paniculata</i>

Gui-Yang WANG; Ting WEN; Fei-Fei LIU; Hai-Yan TIAN; Chun-Lin FAN; Xiao-Jun HUANG; Wen-Cai YE; Ying WANG

doi:10.3724/SP.J.1009.2017.00458

Gui-Yang WANG, Ting WEN, Fei-Fei LIU, Hai-Yan TIAN, Chun-Lin FAN, Xiao-Jun HUANG, Wen-Cai YE, Ying WANG. Two new diterpenoid lactones isolated from Andrographis paniculata[J]. Chinese Journal of Natural Medicines, 2017, 15(6): 458-462. DOI: 10.3724/SP.J.1009.2017.00458

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Two new diterpenoid lactones isolated from Andrographis paniculata

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In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside ( 1 ) and 14-deoxy-15-methoxy-androg-rapholide ( 2 ), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.

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Two new diterpenoid lactones isolated from Andrographis paniculata

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