Tangeretin: A systematic exploration of its sources, structural chemistry, therapeutic profile and strategies for optimizing bioavailability

Tangeretin, a polymethoxylated flavonoid, predominant in citrus fruits has garnered significant scientific interest due to its diverse bioactive properties. Numerous studies have highlighted its potential to mitigate chronic conditions by modulating key signaling pathways. This comprehensive review meticulously delineates the intricate profile of tangeretin, encompassing its origin, nutritional aspects, and pharmacological efficacy. An in-depth analysis of structural chemistry of tangeretin, elucidating its unique polymethoxylation with implications on bioactivity, has been addressed herewith. An exhaustive assessment of tangeretin's potential across a spectrum of disorders, including cancer, neurodegeneration, and metabolic disorders, supported by robust preclinical evidence, suggests its promising role in attenuating disease progression. Obscurities related to tangeretin's bioavailability have also been addressed with emphasis on cutting-edge strategies and technological advancements aimed at optimizing its therapeutic effectiveness. By integrating existing research and identifying emerging trends, this review provides a critical framework for advancing the utilization of tangeretin in preventive and therapeutic landscape.