Recent advances in peptide-based therapy: Challenges, strategies and future perspectives

Peptide-base therapy have garnered significant attention in cancer, diabetes, bacterial infection, and neurodegenerative diseases owing to their promising therapeutic properties and improved safety. This review provides a comprehensive overview of the major trends in peptide drug discovery and development. It emphasizes the preclinical strategies aimed at enhancing peptide stability, specificity, and improve pharmacokinetic properties and assess the application and current difficulties of peptide drugs in these diseases. Also, it illustrates the pharmaceutical areas where peptide drugs have significant potential and analyzes the challenges that must be overcome in the future, which aims to bring valuable insights and references for the further development of peptide drugs.