LIU Na, SONG Mei-Na, ZHANG Qian-Qian, WU Cong, ZHU Kong-Kai, SUN Yu-Lin, LI Meng-Ru, YANG Feng-Ying, FENG Run-Liang, ZHANG Yu-Ying, ZHANG Hua. GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation [J].Chin J Nat Med, 2022, 20(1): 67-73. doi: 10.1016/S1875-5364(21)60108-5
Citation: LIU Na, SONG Mei-Na, ZHANG Qian-Qian, WU Cong, ZHU Kong-Kai, SUN Yu-Lin, LI Meng-Ru, YANG Feng-Ying, FENG Run-Liang, ZHANG Yu-Ying, ZHANG Hua. GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation [J].Chin J Nat Med, 2022, 20(1): 67-73. doi: 10.1016/S1875-5364(21)60108-5

GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation

  • Chemical investigation of the culture extract of an endophytic Penicillium citrinum from Dendrobium officinale, afforded nine citrinin derivatives ( 19 ) and one peptide-polyketide hybrid GKK1032B ( 10 ). The structures of these compounds were determined by spectroscopic methods. The absolute configurations of 1 and 2 were determined for the first time by calculation of electronic circular dichroism (ECD) data. Among them, GKK1032B ( 10 ) showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49 μmol·L–1, and a primary mechanistic study revealed that it induced the apoptosis of MG63 cells via caspase pathway activation.
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