Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410

Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A ( 1) and B ( 2) , along with three known compounds 3 − 5 , were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp. NF2410. The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data. Furthermore, compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.