Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors

A series of novel pyrano2, 3-dtrizaole compounds were synthesized and their α-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC₅₀ 74.0 ± 1.3 μmol·L⁻¹) than acarbose. The molecular docking revealed that compound 10f could bind to α-glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α-glucosidase inhibitors.