New meroterpenoid compounds from the culture of mushroom Panus lecomtei

Two new meroterpenoid compounds ( 1 and 2 ) together with five known meroterpenoid derivatives ( 3 – 7 ) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HR-ESI-MS spectroscopic data. The biosynthetic pathway of 1 – 7 was postulated. All isolated compounds were evaluated for antibacterial activities against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Bacillus Calmette–Guérin. Compound 3 exhibited weak antibacterial activity against Bacillus Calmette–Guérin with the inhibition rate of 83.6% at 100 μmol·L⁻¹. Other compounds showed no antibacterial activities against all tested pathogens at 100 μmol·L⁻¹.