Three new secoiridoid glycosides from the flower buds of Lonicera japonica

Three new secoiridoid glycosides, named lonijapoglycol A ( 1 ), aldosecolohanin C ( 2 ) and aldosecolohanin B ( 3 ), together with three known ones ( 4–6 ), have been isolated from the flower the buds of Lonicera japonica. All the structures were identified by spectroscopic analyses. Lonijapoglycol A ( 1 ) expressed significant anti-inflammatory activity to inhibit the release of β-glu-curonidase induced by platelet-activating factor in rat polymorphonuclear leukocytes with an IC₅₀ value of 3.76 μmol·L⁻¹.